NEUROPEPTIDE-Y MESSENGER-RNA REGULATION IN RAT SYMPATHETIC-GANGLIA - EFFECT OF RESERPINE

被引：23
作者：
HANZE, J
KUMMER, W
HAASS, M
LANG, RE
机构：
[1] UNIV MARBURG,DEPT PHYSIOL & PATHOPHYSIOL,DEUTSCHHAUSSTR 2,W-3550 MARBURG,GERMANY
[2] UNIV HEIDELBERG,DEPT ANAT,W-6900 HEIDELBERG,GERMANY
[3] UNIV HEIDELBERG,DEPT CARDIOL,W-6900 HEIDELBERG,GERMANY
来源：
NEUROSCIENCE LETTERS | 1991年 / 124卷 / 01期
关键词：
NEUROPEPTIDE-Y; MESSENGER RNA; SYMPATHETIC GANGLIA; RESERPINE;
D O I：
10.1016/0304-3940(91)90836-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To study the mechanism underlying trans-synaptic neuropeptide regulation, mRNA levels of neuropeptide Y were examined in the rat stellate and superior cervical ganglia using a specific neuropeptide Y cRNA probe. Basal levels of neuropeptide Y mRNA were detectable in total RNA extracts from single ganglia. Reserpine induced a large rise in ganglion neuropeptide Y mRNA. Decentralization prevented the increase of neuropeptide Y mRNA content in the ganglia. This suggests that the reserpine induced increase in neuropeptide Y mRNA was dependent on transsynaptic stimulation. Consequently, neuropeptide mRNA levels in sympathetic ganglia may be under the control of preganglionic impulse flow.
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页码：119 / 121
页数：3
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