ANGIOGENIC ACTIVITY OF THE FIBROBLAST AND EPIDERMAL GROWTH-FACTOR

被引：254

作者：

GOSPODAROWICZ, D ^{[1
]}

BIALECKI, H ^{[1
]}

THAKRAL, TK ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,MED CTR,CANC RECH INST,DEPT SURG,SAN FRANCISCO,CA 94143

来源：

EXPERIMENTAL EYE RESEARCH | 1979年 / 28卷 / 05期

关键词：

angiogenesis; cornea; EGF; FGF;

D O I：

10.1016/0014-4835(79)90038-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The angiogenic activities of the fibroblast and epidermal growth factors in vivo have been analyzed using the rabbit cornea as a model. The angiogenic activity of slow-release form of Elwax 40 containing either fibroblast growth factor (FGF) or epidermal growth factor (EGF) at concentrations ranging from 0·5 to 60 μg were compared. A positive response was observed with concentrations of EGF as low as 1 μg per implant. The optimal concentration causing neovascularization in 100% of the cases was 10 μg per implant. With FGF, a positive response was observed at 2·5 μg per implant and the optimal concentration causing neovascularization in 100% of the cases was 25 μg per implant. In both cases, and in contrast with implants of serum albumin, the neovascularization could be seen to progress in the absence of inflammation. © 1979.

引用

页码：501 / 514

页数：14

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