ANGIOGENIC ACTIVITY OF THE FIBROBLAST AND EPIDERMAL GROWTH-FACTOR

被引:254
作者
GOSPODAROWICZ, D [1 ]
BIALECKI, H [1 ]
THAKRAL, TK [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,MED CTR,CANC RECH INST,DEPT SURG,SAN FRANCISCO,CA 94143
关键词
angiogenesis; cornea; EGF; FGF;
D O I
10.1016/0014-4835(79)90038-1
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The angiogenic activities of the fibroblast and epidermal growth factors in vivo have been analyzed using the rabbit cornea as a model. The angiogenic activity of slow-release form of Elwax 40 containing either fibroblast growth factor (FGF) or epidermal growth factor (EGF) at concentrations ranging from 0·5 to 60 μg were compared. A positive response was observed with concentrations of EGF as low as 1 μg per implant. The optimal concentration causing neovascularization in 100% of the cases was 10 μg per implant. With FGF, a positive response was observed at 2·5 μg per implant and the optimal concentration causing neovascularization in 100% of the cases was 25 μg per implant. In both cases, and in contrast with implants of serum albumin, the neovascularization could be seen to progress in the absence of inflammation. © 1979.
引用
收藏
页码:501 / 514
页数:14
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