MICE DEFICIENT IN IL-1-BETA-CONVERTING ENZYME ARE DEFECTIVE IN PRODUCTION OF MATURE IL-1-BETA AND RESISTANT TO ENDOTOXIC-SHOCK

被引：1296
作者：
LI, P
ALLEN, H
BANERJEE, S
FRANKLIN, S
HERZOG, L
JOHNSTON, C
MCDOWELL, J
PASKIND, M
RODMAN, L
SALFELD, J
TOWNE, E
TRACEY, D
WARDWELL, S
WEI, FY
WONG, W
KAMEN, R
SESHADRI, T
机构：
[1] BASF Bioresearch Corporation, Worcester, MA 01605-4314
来源：
CELL | 1995年 / 80卷 / 03期
关键词：
D O I：
10.1016/0092-8674(95)90490-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1 beta after stimulation with lipopolysaccharide. IL-1 alpha production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1 beta, a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis.
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收藏
页码：401 / 411
页数：11
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