CHRONIC MORPHINE ALTERS DOPAMINE TRANSPORTER DENSITY IN THE RAT-BRAIN - POSSIBLE ROLE IN THE MECHANISM OF DRUG-ADDICTION

被引:32
作者
SIMANTOV, R
机构
[1] Department of Molecular Genetics, Virology. The Weizmann Institute of Science, Rehovot
关键词
DRUG REINFORCEMENT; OPIOID; NUCLEUS ACCUMBENS; TRANSPORTER;
D O I
10.1016/0304-3940(93)90360-W
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of acute or chronic morphine treatment on dopamine transporters was studied with the selective transporter blocker [H-3]GBR12935. Chronic, but not acute treatment of rats with morphine significantly decreased the B-max of [H-3]GBR12935 binding to membranes from the anterior basal forebrain, that includes the nucleus accumbens, but had no such effect on binding to striatum membranes. No effect on the affinity (K-d) of the radioligand to either one of the two brain regions was observed. The selectivity of morphine interaction with the dopamine system was tested with a ligand that binds selectively to serotonin transporters, [H-3]citalopram. Neither acute nor chronic morphine altered [H-3]citalopram binding to the anterior basal forebrain, or the striatum membranes. It is suggested, therefore, that chronic morphine treatment has a long-lasting and selective effect on the activity of dopamine transporters in the dopaminergic reward pathway, but not in the striatum.
引用
收藏
页码:121 / 124
页数:4
相关论文
共 27 条
[1]   PROFOUND DEPRESSION OF MESOLIMBIC DOPAMINE RELEASE AFTER MORPHINE-WITHDRAWAL IN DEPENDENT RATS [J].
ACQUAS, E ;
CARBONI, E ;
DICHIARA, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 193 (01) :133-134
[3]   RETARDATION OF CEREBRAL DOPAMINE TURNOVER AFTER MORPHINE WITHDRAWAL AND ITS ENHANCED ACCELERATION BY ACUTE MORPHINE ADMINISTRATION IN RATS [J].
ATTILA, LMJ ;
AHTEE, L .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1984, 327 (03) :201-207
[4]   [H-3] GBR-12935 - A SPECIFIC HIGH-AFFINITY LIGAND FOR LABELING THE DOPAMINE TRANSPORT COMPLEX [J].
BERGER, P ;
JANOWSKY, A ;
VOCCI, F ;
SKOLNICK, P ;
SCHWERI, MM ;
PAUL, SM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 107 (02) :289-290
[5]   STIMULANT EFFECTS OF ENKEPHALIN MICRO-INJECTION INTO THE DOPAMINERGIC A10 AREA [J].
BROEKKAMP, CLE ;
PHILLIPS, AG ;
COOLS, AR .
NATURE, 1979, 278 (5704) :560-562
[6]   MORPHINE AND DELTA-OPIATE AGONISTS LOCALLY STIMULATE INVIVO DOPAMINE RELEASE IN CAT CAUDATE-NUCLEUS [J].
CHESSELET, MF ;
CHERAMY, A ;
REISINE, TD ;
GLOWINSKI, J .
NATURE, 1981, 291 (5813) :320-322
[7]  
DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
[8]  
DICHIARA G, 1988, J PHARMACOL EXP THER, V244, P1067
[10]   MORPHINE-INDUCED ACTIVATION OF A10 DOPAMINE NEURONS IN THE RAT [J].
GYSLING, K ;
WANG, RY .
BRAIN RESEARCH, 1983, 277 (01) :119-127