LONG-TERM EFFECTS OF POSTNATAL HYPOXIA AND FLUNARIZINE ON THE DOPAMINERGIC SYSTEM

被引：3
作者：
LUN, A
BERNDT, C
GROSS, J
FISCHER, HD
BERGSTRASSER, E
SCHELLER, D
机构：
[1] MED ACAD CARL GUSTAV CARUS,INST PHARMACOL,D-01109 DRESDEN,GERMANY
[2] JANSSEN RES FDN,D-41470 NEUSS,GERMANY
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 04期
关键词：
DOPAMINE; FLUNARIZINE; HYPOXIA; LEARNING BEHAVIOR; LONG-TERM EFFECT; STRIATUM;
D O I：
10.1016/0091-3057(93)90215-F
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Long-term changes of learning behavior and of the striatal dopaminergic system were observed in a rat model of early postnatal hypoxia. Striatal dopamine (DA) concentration, K+-stimulated DA release from slices, and DA uptake into crude synaptosomal preparations (S1 fractions) were used as markers of the striatal DAergic system. Active avoidance learning was tested as behavioral criterion. Cyclodextrin and flunarizine were found to produce long-term effects on the DAergic system in control animals. While cyclodextrin normalized hypoxia-induced effects in DA release, flunarizine prevented those in DA uptake and improved avoidance learning.
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页码：867 / 871
页数：5
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