RESPONSIVE POLYMER SYSTEMS FOR CONTROLLED DELIVERY OF THERAPEUTICS

被引：55
作者：
KOST, J [1 ]
LANGER, R [1 ]
机构：
[1] MIT, DEPT CHEM ENGN, CAMBRIDGE, MA 02139 USA
来源：
TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 04期
关键词：
D O I：
10.1016/0167-7799(92)90194-Z
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).
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页码：127 / 131
页数：5
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