EFFECT OF SOME ARSENIC ANTAGONISTS ON THE TOXICITY, DISTRIBUTION AND EXCRETION OF ARSENITE AND ARSENATE IN RATS

被引：12

作者：

HILMY, AM ^{[1
]}

ELDOMIATY, NA ^{[1
]}

KAMAL, MA ^{[1
]}

MOHAMED, MA ^{[1
]}

ABOUSAMRA, WE ^{[1
]}

机构：

[1] AIN SHAMS UNIV,FAC MED,DEPT HYG,CAIRO,EGYPT

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 99卷 / 03期

关键词：

CHELATING-AGENTS; SODIUM ARSENITE; MICE; TRIVALENT; METALS; ACID;

D O I：

10.1016/0742-8413(91)90256-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Arsenite and arsenate poisoned rats were treated with either BAL (2,3-dimercapto-1-propanol), penicillamine (PA) (beta-beta-dimethyl cystein) or selenium (Se) (as sodium selenite). 2. The minimal dose of each antagonist that treated arsenic-induced lethality (causing 100% survival) was the same for both arsenite and arsenate. 3. Arsenic mobilization from the tissues (blood, kidney, liver, lungs, spleen, muscles, brain, heart) and its excretion in urine and feces were higher in arsenite-intoxicated animals than in arsenate-intoxicated ones. 4. The effect of each antagonist, when injected alone, on the urinary and fecal excretion of endogenous metals (Cu, Zn, Fe, Ca and Mg) was also examined. 5. The results indicated marked differences in the relative ability of BAL, PA and Se to increase the excretion of the metals.

引用

页码：357 / 362

页数：6

共 17 条

[1] EFFECT OF PENICILLAMINE ON SOME METALS AND METALLOPROTEINS IN RAT [J].