Identification and Characterization of Forced Degraded Impurities of Fenoxazoline Using Chromatographic and Spectroscopic Techniques

被引：0

作者：

Indumathi, K. V. S. ^{[1
]}

Rao, Someshwara N. ^{[1
]}

Rao, B. M. ^{[1
]}

机构：

[1] SDS Labs Private Ltd, TTC Ind Area, MIDC Mahape, EL-115, Navi Mumbai 400701, Maharashtra, India

来源：

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2015年 / 6卷 / 01期

关键词：

HPLC; -; Fenoxazoline; Degradant; Impurities and assign;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A selective specific and sensitive High Pressure Liquid Chromatography method was developed for determination of Fenoxazoline degradation impurities. The chromatographic separation was achieved on Shimadzu LC-2010 with PDA system and Kromasil C18 column using gradient elution of mobile phase. The present study is aim to degrade the product using different degradation conditions. The degraded products were subjected to LC-MS to find out the impurities. Based on the mass of impurities the structures were assigned. The proposed method was successfully employed for estimation of Fenoxazoline impurities in pharmaceutical preparations.

引用

页码：486 / 498

页数：13