Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review

被引：4

作者：

Slowiczek, Lindsay ^{[1
]}

Hein, Darren J. ^{[2
]}

Cochrane, Zara Risoldi ^{[1
,3
]}

Gregory, Philip J. ^{[1
,3
]}

机构：

[1] Creighton Univ, Ctr Drug Informat & Evidence Based Practice, Omaha, NE 68178 USA

[2] Creighton Univ, Ctr Drug Informat & Evidence Based Practice, Pharm Practice, Omaha, NE 68178 USA

[3] Creighton Univ, Pharm Practice, Omaha, NE 68178 USA

来源：

NEONATAL NETWORK | 2018年 / 37卷 / 06期

关键词：

neonatal abstinence syndrome (NAS); neonatal withdrawal; pharmacology;

D O I：

10.1891/0730-0832.37.6.365

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Purpose: To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS). Design: Systematic review. Sample: PubMed, Google Scholar, Cochrane library, CINAHL, IPA, American Academy of Pediatrics, and clinicaltrials.gov were systematically searched to identify randomized controlled trials (RCTs) and observational studies. comparing morphine and methadone for NAS. Outcomes: LOS, LOT, adverse effects. Results: One RCT, two cohort studies, and two chart reviews met inclusion criteria. Each had a low risk of bias. LOS ranged from 12.08 to 36 days with morphine and 21 to 44.23 days with methadone. LOT ranged from 7.46 to 22.9 days (morphine) and 13.9 to 38.08 days (methadone). Adverse effects were not reported. Clinical evidence comparing morphine to methadone for NAS treatment is limited and conflicting. A recommendation for one over the other cannot be made based on these outcomes.

引用

页码：365 / 371

页数：7

共 18 条

[1] Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial [J].

Brown, M. S. ;

Hayes, M. J. ;

Thornton, L. M. .

JOURNAL OF PERINATOLOGY, 2015, 35 (04) :278-283

[2] Efficacy and safety of the drugs used to reverse direct oral anticoagulants: a systematic review and meta-analysis [J].

da Luz, Luis Teodoro ;

Marchand, Mylene ;

Nascimento, Bartolomeu ;

Tien, Homer ;

Nathens, Avery ;

Shah, Prakesh .

TRANSFUSION, 2017, 57 (07) :1834-1846

[3] Increase in Prescription Opioid Use During Pregnancy Among Medicaid-Enrolled Women [J].

Desai, Rishi J. ;

Hernandez-, Sonia ;

Bateman, Brian T. ;

Huybrechts, Krista F. .

OBSTETRICS AND GYNECOLOGY, 2014, 123 (05) :997-1002

[4] A Multicenter Cohort Study of Treatments and Hospital Outcomes in Neonatal Abstinence Syndrome [J].

Hall, Eric S. ;

Wexelblatt, Scott L. ;

Crowley, Moira ;

Grow, Jennifer L. ;

Jasin, Lisa R. ;

Klebanoff, Mark A. ;

McClead, Richard E. ;

Meinzen-Derr, Jareen ;

Mohan, Vedagiri K. ;

Stein, Howard ;

Walsh, Michele C. .

PEDIATRICS, 2014, 134 (02) :E527-E534

[5]

Higgins JPT., 2017, COCHRANE HDB SYSTEMA, V5

[6] Neonatal Drug Withdrawal [J].

Hudak, Mark L. ;

Tan, Rosemarie C. .

PEDIATRICS, 2012, 129 (02) :E540-E560

[7] Treating Women Who Are Pregnant and Parenting for Opioid Use Disorder and the Concurrent Care of Their Infants and Children: Literature Review to Support National Guidance [J].

Klaman, Stacey L. ;

Isaacs, Krystyna ;

Leopold, Anne ;

Perpich, Joseph ;

Hayashi, Susan ;

Vender, Jeff ;

Campopiano, Melinda ;

Jones, Hendree E. .

JOURNAL OF ADDICTION MEDICINE, 2017, 11 (03) :178-190

[8]

Ko JY, 2016, MMWR-MORBID MORTAL W, V65, P799, DOI 10.15585/mmwr.mm6531a2

[9]

Lainwala Shabnam, 2005, Adv Neonatal Care, V5, P265, DOI 10.1016/j.adnc.2005.06.003

[10]

Liberati A, 2009, PLOS MED, V6, DOI [10.1371/journal.pmed.1000100, 10.7326/0003-4819-151-4-200908180-00136, 10.1136/bmj.b2700]

← 1 2 →