SEPARATION FROM RUSSELLS VIPER VENOM OF ONE FRACTION REACTING WITH FACTOR X AND ANOTHER REACTING WITH FACTOR V

被引：132
作者：
SCHIFFMAN, S
THEODOR, I
RAPAPORT, SI
机构：
[1] Departments of Medicine and Biochemistry, University of Southern California, School of Medicine, Los Angeles
来源：
BIOCHEMISTRY | 1969年 / 8卷 / 04期
关键词：
D O I：
10.1021/bi00832a014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The clotting activities in Russell's viper venom which react with either factor X or V have been separated from whole venom by chromatography on Sephadex G-200. The fraction activating factor X, which has a molecular weight around 145,000, functions as a catalyst in a calcium-dependent reaction. The fraction reacting with factor V, which has a molecular weight around 10,000-20,000, is consumed in a reaction requiring no added cofactors. Neither factor V activating fraction nor whole venom appears to react with factor VIII. © 1969, American Chemical Society. All rights reserved.
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页码：1397 / +
页数：1
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