EFFECTS OF D,L-PROPRANOLOL ON APOMORPHINE INDUCED STEREOTYPED BEHAVIOR IN RATS

被引：4

作者：

POLI, A ^{[1
]}

PALERMONETO, J ^{[1
]}

机构：

[1] UNIV SAO PAULO, SCH VET, DEPT PHARMACOL & TOXICOL, BR-05340 SAO PAULO, BRAZIL

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1987年 / 18卷 / 02期

关键词：

D O I：

10.1016/0306-3623(87)90241-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of d,l propranolol on stereotyped behaviour induced by apomorphine administration was studied quantitatively. d,l Propranolol caused a 2.5 leftward displacement of the control dose-response curve constructed to apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 1.87 .+-. 0.38 to 0.74 .+-. 0.17. The potentiation was dependent on both d,l-propranolol and apomorphine doses. Results are discussed in the light of a possible interference of the central noradrenergic systems with the expression of dopaminergic-induced stereotyped behavior.

引用

页码：149 / 152

页数：4

共 23 条

[1] EVIDENCE FOR DOPAMINE RECEPTOR STIMULATION BY APOMORPHINE
ANDEN, NE
RUBENSON, A
FUXE, K
HOKFELT, T
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1967, 19 (09) : 627 - &
[2] ADRENERGIC-RECEPTOR BLOCKING-AGENTS - EFFECTS ON CENTRAL NORADRENALINE AND DOPAMINE RECEPTORS AND ON MOTOR ACTIVITY
ANDEN, NE
STROMBOM, U
[J]. PSYCHOPHARMACOLOGIA, 1974, 38 (02): : 91 - 103
[3] PHARMACOLOGICAL EVIDENCE FOR A STIMULATION OF DOPAMINE NEURONS BY NORADRENALINE NEURONS IN BRAIN
ANDEN, NE
GRABOWSKA, M
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 39 (02) : 275 - 282
[4] NOREPINEPHRINE-DOPAMINE INTERACTIONS AND BEHAVIOR
ANTELMAN, SM
CAGGIULA, AR
[J]. SCIENCE, 1977, 195 (4279) : 646 - 653
[5] BIOLOGICAL PROPERTIES OF OPTICAL ISOMERS OF PROPRANOLOL AND THEIR EFFECTS ON CARDIAC ARRHYTHMIAS
BARRETT, AM
CULLUM, VA
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1968, 34 (01) : 43 - +
[6] A QUANTITATIVE STUDY OF CHOLINERGIC-DOPAMINERGIC INTERACTIONS IN THE CENTRAL NERVOUS-SYSTEM
DESOUZA, H
PALERMONETO, J
[J]. PHARMACOLOGY, 1982, 24 (04) : 222 - 229
[7] DILLIER N, 1978, THESIS U BERNA
[8] DOLLERY CT, 1969, CLIN PHARMACOL THER, V10, P765
[9] EHRINGER H, 1960, KLIN WOCHENSCHR, V38, P1238
[10] ELIASH S, 1971, BRIT J PHARMACOL, V43, P287

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