Long non-coding RNA-mediated regulation of glucose homeostasis and diabetes

被引:2
作者
Sun, Xinghui [1 ]
Wong, Danny [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Cardiovasc Div, 77 Ave Louis Pasteur,NRB 742, Boston, MA 02115 USA
来源
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE | 2016年 / 6卷 / 02期
关键词
Long non-coding RNAs; glucose; diabetes;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Long non-coding RNAs (lncRNAs) represent an important class of non-coding RNAs that plays key roles in regulating the expression of genes in health and disease. Accumulating genetic, experimental, and epidemiological studies highlight a growing list of lncRNAs that control glucose homeostasis and diabetic pathologies and complications. Through interactions with chromatin, RNA, and protein, lncRNAs modulate chromatin modification, mRNA stability, microRNA activity, and the function of proteins such as transcription factors. This review highlights emerging concepts in lncRNA-mediated control of glucose homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of diabetes and its complications.
引用
收藏
页码:17 / 25
页数:9
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