Long non-coding RNA-mediated regulation of glucose homeostasis and diabetes

被引：2
作者：
Sun, Xinghui [1 ]
Wong, Danny [1 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Cardiovasc Div, 77 Ave Louis Pasteur,NRB 742, Boston, MA 02115 USA
来源：
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE | 2016年 / 6卷 / 02期
关键词：
Long non-coding RNAs; glucose; diabetes;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Long non-coding RNAs (lncRNAs) represent an important class of non-coding RNAs that plays key roles in regulating the expression of genes in health and disease. Accumulating genetic, experimental, and epidemiological studies highlight a growing list of lncRNAs that control glucose homeostasis and diabetic pathologies and complications. Through interactions with chromatin, RNA, and protein, lncRNAs modulate chromatin modification, mRNA stability, microRNA activity, and the function of proteins such as transcription factors. This review highlights emerging concepts in lncRNA-mediated control of glucose homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of diabetes and its complications.
引用
收藏
页码：17 / 25
页数：9
相关论文
共 68 条
  • [1] Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy
    Alvarez, M. Lucrecia
    Khosroheidari, Mahdieh
    Eddy, Elena
    Kiefer, Jeff
    [J]. PLOS ONE, 2013, 8 (10):
  • [2] Functional Characterization of the Plasmacytoma Variant Translocation 1 Gene (PVT1) in Diabetic Nephropathy
    Alvarez, M. Lucrecia
    DiStefano, Johanna K.
    [J]. PLOS ONE, 2011, 6 (04):
  • [3] A Genome-Wide Association Study for Diabetic Retinopathy in a Japanese Population: Potential Association with a Long Intergenic Non-Coding RNA
    Awata, Takuya
    Yamashita, Hisakuni
    Kurihara, Susumu
    Morita-Ohkubo, Tomoko
    Miyashita, Yumi
    Katayama, Shigehiro
    Mori, Keisuke
    Yoneya, Shin
    Kohda, Masakazu
    Okazaki, Yasushi
    Maruyama, Taro
    Shimada, Akira
    Yasuda, Kazuki
    Nishida, Nao
    Tokunaga, Katsushi
    Koike, Asako
    [J]. PLOS ONE, 2014, 9 (11):
  • [4] PARENTAL IMPRINTING OF THE MOUSE H19 GENE
    BARTOLOMEI, MS
    ZEMEL, S
    TILGHMAN, SM
    [J]. NATURE, 1991, 351 (6322) : 153 - 155
  • [5] Long Noncoding RNAs: Cellular Address Codes in Development and Disease
    Batista, Pedro J.
    Chang, Howard Y.
    [J]. CELL, 2013, 152 (06) : 1298 - 1307
  • [6] Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?
    Bonnefond, Amelie
    Froguel, Philippe
    [J]. CELL METABOLISM, 2015, 21 (03) : 357 - 368
  • [7] THE PRODUCT OF THE H19 GENE MAY FUNCTION AS AN RNA
    BRANNAN, CI
    DEES, EC
    INGRAM, RS
    TILGHMAN, SM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) : 28 - 36
  • [8] Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
    Cabili, Moran N.
    Trapnell, Cole
    Goff, Loyal
    Koziol, Magdalena
    Tazon-Vega, Barbara
    Regev, Aviv
    Rinn, John L.
    [J]. GENES & DEVELOPMENT, 2011, 25 (18) : 1915 - 1927
  • [9] Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs
    Chen, Geng
    Qiu, Chengxiang
    Zhang, Qipeng
    Liu, Bing
    Cui, Qinghua
    [J]. HUMAN MUTATION, 2013, 34 (02) : 338 - 344
  • [10] The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
    Derrien, Thomas
    Johnson, Rory
    Bussotti, Giovanni
    Tanzer, Andrea
    Djebali, Sarah
    Tilgner, Hagen
    Guernec, Gregory
    Martin, David
    Merkel, Angelika
    Knowles, David G.
    Lagarde, Julien
    Veeravalli, Lavanya
    Ruan, Xiaoan
    Ruan, Yijun
    Lassmann, Timo
    Carninci, Piero
    Brown, James B.
    Lipovich, Leonard
    Gonzalez, Jose M.
    Thomas, Mark
    Davis, Carrie A.
    Shiekhattar, Ramin
    Gingeras, Thomas R.
    Hubbard, Tim J.
    Notredame, Cedric
    Harrow, Jennifer
    Guigo, Roderic
    [J]. GENOME RESEARCH, 2012, 22 (09) : 1775 - 1789
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