APPLICATION OF THE SOLID DISPERSION METHOD TO THE CONTROLLED RELEASE OF MEDICINE .3. CONTROL OF THE RELEASE RATE OF SLIGHTLY WATER-SOLUBLE MEDICINE FROM SOLID DISPERSION GRANULES

被引:0
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作者
YUASA, H
TAKAHASHI, H
OZEKI, T
KANAYA, Y
UENO, M
机构
[1] TOKYO COLL PHARM, 1432-1 HORINOUCHI, HACHIOJI, TOKYO 19203, JAPAN
[2] NISSIN FLOUR MILLING CO LTD, IRUMA, SAITAMA 354, JAPAN
关键词
SLIGHTLY WATER SOLUBLE MEDICINE; FLURBIPROFEN; SOLID DISPERSION; GRANULE; WATER SOLUBLE POLYMER; RELEASE RATE;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
In order to control the release rate of slightly water soluble medicine by using the solid dispersion (SD) method, the SD was prepared with a water soluble polymer and the slightly soluble medicine, and the medicine release from the solid dispersion granules was studied. The SD granules were prepared by the evaporation of ethanol after dissolving into ethanol a slightly water soluble medicine (flurbiprofen (FP)) and soluble polymers (hydroxypropyl cellulose (HPC)). HPC has four grades of molecular weight. The release rate of FP from SD was measured by the rotating basket method (JP XII). The release rate of FP from the SD granules was markedly larger than that from FP powder, and it was larger with a lower HPC molecular weight. It is speculated that these results were mainly based on the molecular dispersion state of FP and HPC in SD.
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页码:397 / 399
页数:3
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