VARIATIONS OF PLASMA APOLIPOPROTEIN-A1 AND APOLIPOPROTEIN-B INDUCED IN LIVER PATIENTS BY INFUSIONS OF S-ADENOSYL-L-METHIONINE

25 patients affected by liver cirrhosis, alcoholic or post-necrotic were included in the study. 15 out of them were given an infusion of S-adenosyl-L-methionine 250 mg in saline 500 ml for ten days; 10 patients received for the same time period 500 ml of saline enriched with g 1 of vitamin C. Before starting treatment and at the end plasma values of cholesterol, triglyce rides, apo-AI and apo-B were determined. In patients who received treatment with S-adenosyl-L-methionine values of apo-AI increased significantly while apo-B underwent a not significant decrease. In the controls no significant variations of the various examined parameters were observed. © 1979 The Italian Pharmacological Society.