DORSOVENTRAL PATTERN-FORMATION IN DROSOPHILA - SIGNAL TRANSDUCTION AND NUCLEAR TARGETING

被引：113
作者：
GOVIND, S
STEWARD, R
机构：
来源：
TRENDS IN GENETICS | 1991年 / 7卷 / 04期
关键词：
D O I：
10.1016/0168-9525(91)90086-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The maternal determinants of dorsoventral polarity of the Drosophila embryo are derived from somatic and germ-line components of the egg chamber. During oogenesis, asymmetry seems to be established by a signal transduction process. This process is thought to provide the developing embryo with a ventral signal responsible for determining the embryonic axis. Through a set of interactions that may involve signal transduction and proteolytic cascade events, positional information is generated in the form of a graded distribution of dorsal protein in blastoderm nuclei. Different levels of dorsal protein result in asymmetric expression of zygotic genes that ultimately specify cell fate.
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页码：119 / 125
页数：7
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