The stability comparison of purified bee venom and bee venom melittin in aqueous solution

被引：0

作者：

Park, Jung Keun ^{[1
]}

Shen, Chang Zhe ^{[1
]}

Kim, Choul Goo ^{[1
]}

Kim, Il Kwang ^{[2
]}

机构：

[1] Chungjin Biotech Co Ltd, F4,15 Sungan2 Gil, Ansan 426791, Gyeonggi Do, South Korea

[2] Wonkwang Univ, N CosmeCeu Co Ltd, Business Incubator 202,Iksandae Ro 460, Iksan Si 50538, Jeonbuk, South Korea

来源：

ANALYTICAL SCIENCE AND TECHNOLOGY | 2016年 / 29卷 / 04期

关键词：

Stability; Quantitative analysis; Prep-HPLC; Purified bee venom (PBV); Bee venom melittin (BVM);

D O I：

10.5806/AST.2016.29.4.194

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The stability comparison tests on purified bee venom (PBV) and bee venom melittin (BVM) in different conditions of temperature, solvent, and concentration were studied. High purity BVM (98.2 %) was separated from PBV by prep-HPLC (column, C-4) and used to stability tests in aqueous phase. The stability of the PBV has been increased in the saline solution, while BVM was reduced. In distilled water, the stability of PBV has been reduced, while BVM showed an increasing result. As a result, the appropriate conditions for maintaining the long term stability of BVM were found to be the low temperature (4 degrees C), distilled water, and concentration (1.0 mg/mL).

引用

页码：194 / 201

页数：8

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