SPORADIC ALS/MND - A GLOBAL NEURODEGENERATION WITH RETROVIRAL INVOLVEMENT

被引：22
作者：
WESTARP, ME
FERRANTE, P
PERRON, H
BARTMANN, P
KORNHUBER, HH
机构：
[1] FDN DON GNOCCHI,I-20148 MILAN,ITALY
[2] ECOLE NORMALE SUPER LYON,CNRS BIOMERIEUX,F-69364 LYON,FRANCE
[3] UNIV BONN,DEPT PAEDIAT,D-53113 BONN,GERMANY
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 129卷
关键词：
AMYOTROPHIC LATERAL SCLEROSIS; AUTOSOMAL GENE TRANSFER; HUMAN T LYMPHOTROPIC VIRUS (HTLV); NEUROTOXICITY; RETROVIRAL ANTIBODIES; PARKINSONS DISEASE; CIRCULATING IGG-IMMUNOCOMPLEXES; HIV-1; HIV-2;
D O I：
10.1016/0022-510X(95)00087-I
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Sporadic amyotrophic lateral sclerosis may be an aetiologically heterogenous disease. We confirmed elevated circulating IgG immune complexes, and altered IgG seroreactivities against human retroviral antigens (HIV-2 and HTLV immunoblots) in overlapping subgroups of patients. Together with preliminary findings of a positive polymerase chain reactivity for human T-lymphotropic virus (HTLV.tax/rex) in blood leukocytes of 5 out of 14 sALS patients, we interpret this as evidence for a retroviral involvement in this relentlessly progressive, often asymmetrically spreading neurodegeneration. The possibility of a secondary phenomenon seems unlikely, yet cannot be completely ruled out.
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收藏
页码：145 / 147
页数：3
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