QUANTITATIVE-DETERMINATION OF PIVALIC ACID IN DIPIVEFRIN-CONTAINING OPHTHALMIC SOLUTIONS BY GAS-CHROMATOGRAPHY

被引：2
|
作者：
HALL, L
机构：
[1] Pharmaceutical Sciences, Pharmaceutical Analysis Department, Allergan Pharmaceuticals, Irvine, CA 92715
来源：
JOURNAL OF CHROMATOGRAPHY A | 1994年 / 679卷 / 02期
关键词：
D O I：
10.1016/0021-9673(94)80585-7
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A capillary gas chromatographic method was developed for the analysis of the degradation product pivalic acid in dipivefrin-containing ophthalmic solutions. The linear calibration range was 1.02 to 102 mu g/ml (r = 0.999) and recoveries were greater than 98%. The relative standard deviation was less than 4.2%. The method can be used to accurately monitor pivalic acid levels for routine quality control and is simple and reliable.
引用
收藏
页码：397 / 401
页数：5
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