Need for expanded HPV genotyping for cervical screening

被引:59
作者
Cuzick, Jack [1 ]
Wheeler, Cosette [2 ]
机构
[1] Queen Mary Univ London, Wolfson Inst Prevent Med, Charterhouse Sq, London EC1M 6BQ, England
[2] Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA
关键词
D O I
10.1016/j.pvr.2016.05.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The focus for HPV genotyping has largely been on types 16 and 18, based on their high prevalence in cervix cancer. However screening is focussed on the detection of high grade precursor lesions (CIN3 and CIN2), where other types have a greater role. While HPV16 retains its high predictive value in this context, HPV31 and especially HPV33 emerge as important types with higher positive predictive values (PPVs) than HPV18. Additionally full typing indicates that types 39, 56, 59 and 68 have much lower PPVs than types 16,18, 31, 33, 35, 45, 51, 52 and 58 and they should be considered as 'intermediate risk' types, whereas type 66 should not be treated as having an increased risk. Available data are summarized to support this view. (C) 2016 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:112 / 115
页数:4
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