MOLECULAR BIOLOGIC ASPECTS OF HUMAN PROSTATIC-CARCINOMA

被引：0
作者：
NETTO, GJ
HUMPHREY, PA
机构：
[1] WASHINGTON UNIV,BARNES HOSP,MED CTR,DEPT PATHOL,LAUREN V ACKERMAN LAB SURG PATHOL,ST LOUIS,MO 63110
[2] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1994年 / 102卷 / 04期
关键词：
PROSTATE; CANCER; ONCOGENES; GROWTH FACTORS; TUMOR SUPPRESSOR GENES;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Adenocarcinoma of the prostate is the most common noncutaneous malignancy in American men, yet relatively little is known about the molecular mechanisms involved in its initiation and progression. This review surveys the current state of knowledge of selected molecular biological aspects of human prostate cancer. It focuses on four classes of genes implicated in the growth control and cellular differentiation of human prostatic carcinoma: tumor suppressor genes, oncogenes, growth factor genes, and growth factor receptor genes. The relation of changes in structure or expression or both of these genes to pathologic or clinical endpoints is discussed.
引用
收藏
页码：S57 / S64
页数：8
相关论文
共 130 条
[1]   HOMOGENEOUSLY STAINING CHROMOSOMAL REGIONS CONTAIN AMPLIFIED COPIES OF AN ABUNDANTLY EXPRESSED CELLULAR ONCOGENE (C-MYC) IN MALIGNANT NEUROENDOCRINE CELLS FROM A HUMAN-COLON CARCINOMA [J].
ALITALO, K ;
SCHWAB, M ;
LIN, CC ;
VARMUS, HE ;
BISHOP, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1707-1711
[2]  
Bae V. L., 1994, Proceedings of the American Association for Cancer Research Annual Meeting, V35, P272
[3]   RAS ONCOGENES - THEIR ROLE IN NEOPLASIA [J].
BARBACID, M .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1990, 20 (03) :225-235
[4]   THE NEU ONCOGENE ENCODES AN EPIDERMAL GROWTH-FACTOR RECEPTOR-RELATED PROTEIN [J].
BARGMANN, CI ;
HUNG, MC ;
WEINBERG, RA .
NATURE, 1986, 319 (6050) :226-230
[5]   DELETION MAPPING OF CHROMOSOME-8, CHROMOSOME-10, AND CHROMOSOME-16 IN HUMAN PROSTATIC-CARCINOMA [J].
BERGERHEIM, USR ;
KUNIMI, K ;
COLLINS, VP ;
EKMAN, P .
GENES CHROMOSOMES & CANCER, 1991, 3 (03) :215-220
[6]  
BHASKAR V, 1994, HUM PATHOL, V25, P92
[7]  
BOOKSTEIN R, 1993, CANCER RES, V53, P3369
[8]   PROMOTER DELETION AND LOSS OF RETINOBLASTOMA GENE-EXPRESSION IN HUMAN PROSTATE CARCINOMA [J].
BOOKSTEIN, R ;
RIO, P ;
MADREPERLA, SA ;
HONG, F ;
ALLRED, C ;
GRIZZLE, WE ;
LEE, WH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7762-7766
[9]   SUPPRESSION OF TUMORIGENICITY OF HUMAN PROSTATE CARCINOMA-CELLS BY REPLACING A MUTATED RB GENE [J].
BOOKSTEIN, R ;
SHEW, JY ;
CHEN, PL ;
SCULLY, P ;
LEE, WH .
SCIENCE, 1990, 247 (4943) :712-715
[10]   CANCER STATISTICS, 1994 [J].
BORING, CC ;
SQUIRES, TS ;
TONG, T ;
MONTGOMERY, S .
CA-A CANCER JOURNAL FOR CLINICIANS, 1994, 44 (01) :7-26
12345678910