INTRAPERICARDIAL CISPLATIN FOR THE MANAGEMENT OF PATIENTS WITH LARGE MALIGNANT PERICARDIAL-EFFUSION

被引:21
|
作者
TOMKOWSKI, W
SZTURMOWICZ, M
FIJALKOWSKA, A
FILIPECKI, S
FIGURACHOJAK, E
机构
[1] INST TB & PULM DIS,DEPT INTERNAL MED,PL-01138 WARSAW,POLAND
[2] INST TB & PULM DIS,DEPT PATHOL,PL-01138 WARSAW,POLAND
关键词
MALIGNANT PERICARDITIS; INTRAPERICARDIAL CISPLATIN;
D O I
10.1007/BF01240144
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nine patients (seven men and two women), median age 57 years (range 40-68 years), with large malignant pericardial effusion confirmed by cytological examination, were treated with direct intrapericardial administration of cisplatin. After insertion of a polyurethane catheter, fluid was drained and cisplatin (10 mg in 20 mi normal saline) was instilled over 5 min during 5 consecutive days (total cisplatin dose: 50 mg). If fluid reaccumulation occurred the courses were repeated every 3 weeks. All of the patients achieved a complete therapeutic response (no more fluid reaccumulation). The median time of response was 2.8 months (range 1-24 months). Mild nausea occurred in two patients, supraventricular arrythmia in one patient and infectious complications in one patient. Eight patients died because of disease progression without evidence of cardiac tamponade or stricture. Autopsy, performed in 7 cases, revealed neoplastic involvement of the pericardium in all of the patients, but pericardial effusion was seen in one patient only.
引用
收藏
页码:434 / 436
页数:3
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