THERMOANALYTICAL STUDY OF ACECLOFENAC FORMULATIONS WITH REGULAR MAIZE STARCH AND WAXY MAIZE STARCH

被引：0

作者：

Colman, Maristela Denck ^{[1
]}

Ramos, Elaine da Silva ^{[2
]}

de Oliveira, Cristina Soltovski ^{[1
]}

Denck Colman, Tiago Andre ^{[3
]}

Schnitzler, Egon ^{[1
]}

机构：

[1] Univ Estadual Ponta Grossa, Carlos Cavalcanti 4748, BR-84030900 Ponta Grossa, Parana, Brazil

[2] Fed Inst Educ Sci & Technol Parana, Campus Telemaco Borba,Rod PR 160,Km 19-5, Telemaco Borba, Parana, Brazil

[3] Fed Univ Grande Dourados, Fac Sci & Technol, Rodovia Dourados Itahum,Km 12,Caixa Postal 364, BR-79804970 Dourados, MS, Brazil

来源：

JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES | 2016年 / 6卷 / 02期

关键词：

Thermal analysis; aceclofenac; excipient; regular maize starch; waxy maize starch; interaction drug: excipient;

D O I：

10.15414/jmbfs.2016.6.2.828-831

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Production of tablets in pharmaceutical industry often is required to mixture the active ingredient (drug) with an inert material. Starch is shown as a good alternative material to be used as excipient. Thus, in this investigation the techniques: thermogravimetry and derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC as well as thermomicroscopy were performed with aim to verify existence of interactions between aceclofenac (2-[2-[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxalacetic) with regular maize starch and waxy maize starch. Binary and physical mixtures of aceclofenac and starch in ratios 2: 1, 1: 1 and 1: 2 (drug: starch) studied by the instrumental techniques showed that no interactions occurs between the drug and starches in any ratio, being maintained the properties of aceclofenac.

引用

页码：828 / 831

页数：4

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