THERMOANALYTICAL STUDY OF ACECLOFENAC FORMULATIONS WITH REGULAR MAIZE STARCH AND WAXY MAIZE STARCH

被引:0
作者
Colman, Maristela Denck [1 ]
Ramos, Elaine da Silva [2 ]
de Oliveira, Cristina Soltovski [1 ]
Denck Colman, Tiago Andre [3 ]
Schnitzler, Egon [1 ]
机构
[1] Univ Estadual Ponta Grossa, Carlos Cavalcanti 4748, BR-84030900 Ponta Grossa, Parana, Brazil
[2] Fed Inst Educ Sci & Technol Parana, Campus Telemaco Borba,Rod PR 160,Km 19-5, Telemaco Borba, Parana, Brazil
[3] Fed Univ Grande Dourados, Fac Sci & Technol, Rodovia Dourados Itahum,Km 12,Caixa Postal 364, BR-79804970 Dourados, MS, Brazil
关键词
Thermal analysis; aceclofenac; excipient; regular maize starch; waxy maize starch; interaction drug: excipient;
D O I
10.15414/jmbfs.2016.6.2.828-831
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Production of tablets in pharmaceutical industry often is required to mixture the active ingredient (drug) with an inert material. Starch is shown as a good alternative material to be used as excipient. Thus, in this investigation the techniques: thermogravimetry and derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC as well as thermomicroscopy were performed with aim to verify existence of interactions between aceclofenac (2-[2-[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxalacetic) with regular maize starch and waxy maize starch. Binary and physical mixtures of aceclofenac and starch in ratios 2: 1, 1: 1 and 1: 2 (drug: starch) studied by the instrumental techniques showed that no interactions occurs between the drug and starches in any ratio, being maintained the properties of aceclofenac.
引用
收藏
页码:828 / 831
页数:4
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