ANALYSIS OF THE CLINICAL OUTCOMES OF GASTRODUODENAL DISEASES IN YAKUTIA DEPENDING ON THE PRESENCE OF THE CYTOTOXIN-ASSOCIATED GENE A (CAGA) IN THE HELICOBACTER PYLORI

Introduction. The cytotoxin associated gene A (cagA) in the Helicobacter pylori genome is often associated with the formation of cytotoxins and induction of interleukin 8 (IL8) by gastric epithelial cells, which directly affects the immune response and entails inflammatory processes, affecting on clinical outcomes in patients with gastroduodenal diseases, caused by Helicobacter pylori. The clinical outcomes of gastroduodenal diseases, depending on the presence of Helicobacter pylori cagA gene, circulating in Yakutia, were not previously studied. The aim of this work is to study clinical outcomes in patients with gastroduodenal diseases in Yakutia, depending on the presence of the cytotoxin associated gene A in the Helicobacter pylori. Materials and methods. Gastric biopsy specimens were obtained from 311 patients. According to the results of histological analysis, 172 patients had the presence of H. pylori and divided into two groups: chronic gastritis and chronic gastritis with erosions and ulcers. Results. Chronic gastritis was established in 91 samples (52,9%), and the diagnosis of chronic gastritis with erosions and ulcers was established in 81 samples (47,1%). Strains with cagA+ status were identified in 118 samples (68,6%), and cagA- in 54 samples (31,4%). In the group from 18 to 70 years, a higher incidence of cagA+ strains were found in comparison with the group of patients from 3 to 17 years which more often had cagA- strains (p<0,001). The cross-sectional analysis showed that statistically significant differences were found in the cagA+ and cagA- strains between the clinical outcomes within a group of children (chi(2)=9,03, p<0,001) (73,7%). Conclusion. We showed relationship between cagA+ strains of Helicobacter pylori and more severe clinical outcomes (erosions and ulcers) in patients with gastroduodenal diseases in Yakutia. Obtained result confirms previously known data that cagA+ strains are more virulent and pathogenic than cagA- strains of Helicobacter pylori.