CEREBRAL METABOLITE DYNAMICS DURING TEMPORARY COMPLETE ISCHEMIA IN RATS MONITORED BY TIME-SHARED H-1 AND P-31 NMR-SPECTROSCOPY

被引：44
作者：
CHANG, LH
SHIRANE, R
WEINSTEIN, PR
JAMES, TL
机构：
[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT NEUROL SURG, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT RADIOL, SAN FRANCISCO, CA 94143 USA
来源：
MAGNETIC RESONANCE IN MEDICINE | 1990年 / 13卷 / 01期
关键词：
D O I：
10.1002/mrm.1910130103
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The changes in cerebral phosphorus metabolites, intracellular pH, and lactate during 30 min of complete global ischemia and 2 h of reperfusion were monitored by time‐shared 1H and 31P in vivo NMR spectroscopy in rats. After the induction of ischemia, intracellular pH decreased from 7.14 ± 0.01 to 6.32 ± 0.10, and lactate concentration increased from 1.6 ± 0.4 to 15.8 ± 2.5 μmol/g; ATP and phosphocreatine were totally depleted, while inorganic phosphate increased 715 ± 47%. Within 1 h after blood flow was restored, high‐energy phosphates and lactate levels had recovered close to baseline levels. The changes in intracellular pH and lactate levels during ischemia and reperfusion correlated Well. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：6 / 13
页数：8
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