PROSTACYCLIN-DEPENDENT DIFFERENCES IN TXA2 FORMATION BY PLATELETS FROM NORMAL AND ATHEROSCLEROTIC RABBITS

被引：39
作者：
DEMBINSKAKIEC, A [1 ]
RUCKER, W [1 ]
SCHONHOFER, PS [1 ]
机构：
[1] HANOVER UNIV MED,INST PHARMAKOL & TOKIKOL,ABT 2,D-3000 HANOVER 61,FED REP GER
来源：
ATHEROSCLEROSIS | 1979年 / 33卷 / 02期
关键词：
Atherosclerotic rabbits; cAMP; Platelets; Prostacyclin; Thromboxane B[!sub]2[!/sub;
D O I：
10.1016/0021-9150(79)90118-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Intact platelets from atherosclerotic rabbits release more thromboxane B2 (TXB2) and 12-hydroxyeicosatetraenoic acid (HETE) than platelets from normal rabbits following incubation with [l4C]arachidonic acid (AA). In contrast, no difference is found between homogenates of platelets from normal and atherosclerotic animals. PGI2 stimulates CAMP accumulation and inhibits TXB2 formation more potently in intact platelets from atherosclerotic than from normal rabbits, but has no effect on AA metabolism in homogenised platelets. © 1979.
引用
收藏
页码：217 / 226
页数：10
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