PHASE-SEPARATION IN CYTOPLASM, DUE TO MACROMOLECULAR CROWDING, IS THE BASIS FOR MICROCOMPARTMENTATION

被引：175

作者：

WALTER, H

BROOKS, DE

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PATHOL,VANCOUVER,BC V6T 1W5,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER,BC V6T 1W5,CANADA

来源：

FEBS LETTERS | 1995年 / 361卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

AQUEOUS PHASE SYSTEM; CYTOPLASM; MACROMOLECULAR CROWDING; MICROCOMPARTMENTATION; PHASE SEPARATION;

D O I：

10.1016/0014-5793(95)00159-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The macromolecular diversity and concentrations in the fluid phase of cytoplasm constitute conditions necessary and sufficient for aqueous phase separation. Consequences of phase separation in cytoplasm, including its 'compartmentation', are inferred from analogies with the physicochemical properties of aqueous two-phase systems and with the partitioning behavior of biomaterials in them.

引用

页码：135 / 139

页数：5

共 40 条

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GERSHON ND, 1984, P NATL ACAD SCI USA, V82, P5030

[12] AQUEOUS 2-PHASE PROTEIN PARTITIONING USING TEXTILE DYES AS AFFINITY LIGANDS [J].