DEVAZIPIDE (MK-329) ADSORPTION ON MICROCRYSTALLINE CELLULOSE

被引：3

作者：

GHANNAM, MM

GAUTAM, J

RESTAINO, FA

机构：

[1] Pharmaceutical Research and Development, Merck, Sharp and Dohme, West Point, PA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 09期

关键词：

D O I：

10.3109/03639049209069310

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An in-depth evaluation of the adsorption of Devazipide onto microcrystalline cellulose, formulation and/or process optimization procedures to minimize this adsorption are reported. This adsorption was more evident in the 1 mg compared to the 10 mg strength tablet and could be completely eliminated if the microcrystalline cellulose was reduced to < 10%. This adsorption followed the Langmuir Isotherm and was dependent on pH with insignificant amount of adsorption occurring at pH 2.0. At this particular pH, adsorbed drug is easily released.

引用

页码：973 / 996

页数：24