ACTINOMYCIN-D - DISRUPTION OF THE MITOTIC GRADIENT IN THE CLEAVAGE STAGES OF THE SEA-URCHIN EMBRYO

被引：6
作者：
PARISI, E
FILOSA, S
MONROY, A
机构：
[1] UNIV NAPLES,INST HISTOL & EMBRYOL,I-80134 NAPLES,ITALY
[2] ZOOL STN,NAPLES,ITALY
来源：
DEVELOPMENTAL BIOLOGY | 1979年 / 72卷 / 01期
关键词：
D O I：
10.1016/0012-1606(79)90106-4
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
When embryos of Paracentrotus lividus are actinomycin D treated immediately after fertilization, the vegetal-animal mitotic gradient is completely disrupted. On the other hand, if the treatment is started at or after the 16-cell stage (i.e., after the segregation of the micromeres), the mitotic gradient is not affected. The hypothesis is advanced that actinomycin D inhibits a transcriptional event in the micromeres which regulates the synchronization of the cell divisions in the early cleavage stages. © 1979.
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页码：167 / 174
页数：8
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