GENETIC-STUDY OF A NEW EARLY GENE, COMC-ALPHA, OF BACTERIOPHAGE-T4

We have previously shown that an abortive infection of bacteriophage T4 in host Escherichia coli K-12 mutants (tabC) is overcome by a mutant having a mutation, comC-α, being mapped near gene 39. In this study, we performed a genetic analysis of a mutation of comC-α type (comC803). Furthermore, an amber mutant, amB58 comC803, was isolated and the amB58 mutation was demonstrated to be a second-site mutation in the comC-α gene. By deletion mapping, the amB58 mutation was mapped in a region between the left ends of deletions of del(39-56)5 and of del(39-56)11. From these results, we concluded that the comC-α gene is a new early gene. © 1979.