REGULATION OF THE EARLY DEVELOPMENT OF THE NERVOUS-SYSTEM BY GROWTH-FACTORS

被引：7

作者：

BARTLETT, PF

KILPATRICK, TJ

RICHARDS, LJ

TALMAN, PS

MURPHY, M

机构：

[1] Insitute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville, Vic. 3050, The Walter and Eliza Hall

来源：

PHARMACOLOGY & THERAPEUTICS | 1994年 / 64卷 / 03期

基金：

英国医学研究理事会;

关键词：

NEURAL PRECURSORS; CLONAL ANALYSIS; FIBROBLAST GROWTH FACTORS; NEURAL CREST; MULTIPOTENTIALITY; LINEAGE COMMITMENT;

D O I：

10.1016/0163-7258(94)00044-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.

引用

页码：371 / 393

页数：23

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