EPIDERMAL GROWTH-FACTOR, INSULIN-LIKE GROWTH FACTOR-I AND BASIC FIBROBLAST GROWTH-FACTOR MODULATE THE CYTOSTATIC EFFECT OF TUMOR-NECROSIS-FACTOR-ALPHA ON THE BREAST-CANCER CELL-LINE, T47D

被引：7

作者：

PUSZTAI, L ^{[1
]}

LEWIS, CE ^{[1
]}

MCGEE, JO ^{[1
]}

机构：

[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL & BACTERIOL,ACAD BLOCK,OXFORD OX3 9DU,ENGLAND

来源：

CYTOKINE | 1993年 / 5卷 / 02期

关键词：

BFGF; BREAST CANCER; EGF IGF-1; TNF-ALPHA;

D O I：

10.1016/1043-4666(93)90056-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-α (TNF-α) was studied on the breast cancer cell line, T47D. TNF-α completely blocked the potent growth-promoting activity of all three factors on T47D cells. EGF, bFGF and IGF-1 partially antagonized the inhibition of cell growth and thymidine incorporation induced by TNF-α. These data suggest that the growth of these breast cancer cells is regulated, in part, by the antagonistic interaction between the cytostatic effect of TNF-α and the growth-promoting activity of factors such as EGF, IGF-1 and bFGF. © 1993 Academic Press Limited.

引用

页码：169 / 172

页数：4

共 19 条

[1]

BALKWILL FR, 1989, CYTOKINES CANCER THE, P54

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