Sleep apnea is common in patients with coronary artery disease

被引：0
作者：
Prinz, Christian [1 ]
Bitter, Thomas [1 ]
Piper, Cornelia [1 ]
Horstkotte, Dieter [1 ]
Faber, Lothar [1 ]
Oldenburg, Olaf [1 ]
机构：
[1] Ruhr Univ Bochum, Heart & Diabet Ctr North Rhine Westphalia, Dept Cardiol, Bad Oeynhausen, Germany
来源：
WIENER MEDIZINISCHE WOCHENSCHRIFT | 2010年 / 160卷 / 13-14期
关键词：
Prevalence; sleep-disordered breathing; coronary artery disease; chronic inflammation;
D O I：
10.1007/s10354-009-0737-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sleep-disordered breathing (SDB) has a prognostic impact in patients with cardiac diseases. We included 257 patients with preserved left ventricular function and angiographically proven coronary artery disease (CAD). All patients underwent cardiorespiratory polygraphy. In 251 patients high-sensitive Creactive protein and fibrinogen were measured. SDB was documented in 188 patients (apnea-hypopnea-index [AHI] 16.4 +/- 1.9/h): 58 patients presented central sleep apnea (CSA) and 130 patients obstructive sleep apnea (OSA). All patients (73%) with SDB had higher blood fibrinogen levels than those without SDB (p = 0.01). We found 197 patients with CRP-values below the cut-off of 0.5 mg/dl (group 1) and 54 patients with no active infection but CRP > 0.5 mg/dl (group 2). Severity of SDB was significantly higher in group 2 (p = 0.01). SDB has a high prevalence in CAD patients and seems to be associated with chronic inflammation, which may be linked to CAD progression and/or acute coronary events.
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页码：349 / 355
页数：7
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