Prospects for Foamy Viral Vector Anti-HIV Gene Therapy

被引：4

作者：

Nalla, Arun K. ^{[1
]}

Trobridge, Grant D. ^{[1
,2
]}

机构：

[1] Washington State Univ, Coll Pharm, Pharmaceut Sci, Spokane, WA 99202 USA

[2] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA

来源：

BIOMEDICINES | 2016年 / 4卷 / 02期

关键词：

gene therapy; retroviral vector; foamy viruses; anti-HIV transgenes;

D O I：

10.3390/biomedicines4020008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cell gene therapy approaches for Human Immunodeficiency Virus (HIV) infection have been explored in clinical trials and several anti-HIV genes delivered by retroviral vectors were shown to block HIV replication. However, gammaretroviral and lentiviral based retroviral vectors have limitations for delivery of anti-HIV genes into hematopoietic stem cells (HSC). Foamy virus vectors have several advantages including efficient delivery of transgenes into HSC in large animal models, and a potentially safer integration profile. This review focuses on novel anti-HIV transgenes and the potential of foamy virus vectors for HSC gene therapy of HIV.

引用

页数：23

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