LIPOSOME TARGETING TO RAT-BRAIN - EFFECT OF OSMOTIC OPENING OF THE BLOOD-BRAIN-BARRIER

被引：38
|
作者：
SAKAMOTO, A [1 ]
IDO, T [1 ]
机构：
[1] TOHOKU UNIV,CTR CYCLOTRON & RADIOISOTOPE,DIV RADIOPHARMACEUT CHEM,AOBA KU,SENDAI,MIYAGI 980,JAPAN
来源：
BRAIN RESEARCH | 1993年 / 629卷 / 01期
关键词：
BLOOD BRAIN BARRIER; INTRA-CAROTID INJECTION; LIPOSOME; OSMOTIC TREATMENT; SULFATIDE;
D O I：
10.1016/0006-8993(93)90499-D
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or without osmotic treatment by mannitol, we administered liposomes through the internal carotid artery in rats. Sulfatide liposomes could pass the BBB with osmotic treatment, but not without osmotic treatment. Therefore, we propose that the combination method of administration of the reticuloendothelial-system avoiding liposomes with osmotic treatment can be useful for treatment of various kinds of brain diseases.
引用
收藏
页码：171 / 175
页数：5
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