STEREOSELECTIVITY OF PHTHALIMIDO beta-LACTAMS FORMATION: SYNTHESIS OF 3-AMINO beta-LACTAMS THROUGH A FACILE DEPROTECTION REACTION

被引：0

作者：

Paniagua, Armando ^{[1
]}

Yadav, Ram Naresh ^{[1
,2
]}

Chandra, Sunena ^{[1
]}

Banik, Bimal Krishna ^{[1
,3
]}

机构：

[1] Univ Texas Pan Amer, Dept Chem, 1201 West Univ Dr, Edinburg, TX 78539 USA

[2] Veer Bahadur Singh Purvanchal Univ, Fac Engn & Technol, Dept Chem, Jaunpur 222003, UP, India

[3] Community Hlth Syst South Texas, Edinburg, TX 78539 USA

来源：

HETEROCYCLIC LETTERS | 2018年 / 8卷 / 02期

关键词：

Cycloaddition; Phthalimido group; Amino beta-lactam; Deprotection;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of amino beta-lactams is a crucial objective because of the medicinal properties associated with them and the products derived from of them. Stereocontrolled synthesis of phthalimido beta-lactams is performed and cis and trans-phthalimido beta-lactams are deprotected with ethylene diamine (and other reagents) to amino beta-lactams of diverse structures in excellent yield. This reaction is also conducted under solventless conditions to afford identical products.

引用

页码：287 / 295

页数：9

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