TRANSFORMATION OF NIH3T3 CELLS WITH RAS ONCOGENES ABROGATES THE RETINOIC ACID INDUCTION OF TISSUE TRANSGLUTAMINASE

被引：13
作者：
KOSA, K
MEYERS, K
DE LUCA, LM
机构：
[1] NCI, CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB, BETHESDA, MD 20892 USA
[2] NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.2354
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Retinoic acid greatly increases enzyme activity and mRNA expression of the tissue-type transglutaminase enzyme in NIH3T3 cells. This response is blocked in cells transformed with activated H-ras, K-ras or N-ras oncogenes, but not in pSVneo vector transfected cells. Lack of induction by RA of the tissue-type TGase in these ras-transformed fibroblasts suggests intersecting pathways between retinoid action and the ras oncogene. © 1993 Academic Press. All rights reserved.
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页码：1025 / 1033
页数：9
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