PHOSPHOLIPASE-C GAMMA-2 (PLCG2) AND PHOSPHOLIPASE-C GAMMA-1 (PLCG1) MAP TO DISTINCT REGIONS IN THE HUMAN AND MOUSE GENOMES

被引：14
作者：
ARGESON, AC
DRUCK, T
VERONESE, ML
KNOPF, JL
BUCHBERG, AM
HUEBNER, K
SIRACUSA, LD
机构：
[1] THOMAS JEFFERSON UNIV, JEFFERSON CANC INST, DEPT MICROBIOL & IMMUNOL, PHILADELPHIA, PA 19107 USA
[2] GENET INST INC, SMALL MOLEC DRUG DISCOVERY, CAMBRIDGE, MA 02140 USA
来源：
GENOMICS | 1995年 / 25卷 / 01期
关键词：
D O I：
10.1016/0888-7543(95)80106-V
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The phospholipase C gamma-2 (Plcg2) gene encodes an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important be cause of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate. We have now determined the chromosomal location of this gene in the mouse and human genomes. An interspecific backcross involving AEJ/Gn and Mus spretus mice was used to localize the gene in mouse. A rodent/human somatic cell hybrid panel was used to map PLCG2 in the human genome. Our results position PLcg2 in the central region of mouse chromosome 8. We also show that PLCG2 maps to the long arm of human chromosome 16, in the region q22-qter. PLcg2 does not map near its most closely related family member, PLcg1, in either genome, indicating that the mammalian Plcg genes belong to a dispersed family. (C) 1995 Academic Press, Inc.
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页码：29 / 35
页数：7
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