A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-5,7-O-DIMETHYLEUCOMOL AND (S)-5,7-O-DIMETHYLEUCOMOL

被引：28
作者：
DAVIS, FA
CHEN, BC
机构：
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 47期
关键词：
D O I：
10.1016/S0040-4039(00)97181-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in >96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine 9c. © 1990.
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页码：6823 / 6826
页数：4
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