Preparation of Tri-n-alkyl[P-32] phosphine Oxide for latent Treatment of Hepatic Tumors

The element phosphorus, a component of low molecular intermediate and nucleic acid, plays an important role in metabolism in body. And so P-32 and its labeled compounds have been studied in the fields of biology, genetic engineering and so forth. However, P-32 labeling compounds have been insufficiently studied in part of treatment despite many researches on tracers. In line of application research of the [(32) P]H3PO4, we have focused on the LUF (Lipiodol Ultra-Fluid), an oily lymphographic, which have been used in hepatography and have prepared LUF alternatives( tri-n-alkyl[(32) P] phosphine oxide). Comparative materials, Tri-n-alkylphosphine Oxide, have been synthesized with Grignard reaction and yields are 17% for butyl, 29% for octyl and 52% for dodecyl. P-(32) exchange reactions take precedence of Grignard reaction for preparation of precursor [(32) P] POCl3 of tri-n-alkyl[(32) P] phosphine oxide. Exchanging yield is over 96% confirmed of Radio TLC scanner. The labeling yields of tri-n-alkyl[(32) P] phosphine oxide are 91%, 60%, and 96% respectively for butyl, octyl and dodecyl