HEPATOCELLULAR METABOLIC CHANGE AFTER ORTHOTOPIC LIVER-TRANSPLANTATION IN RATS

被引：0

作者：

NAKAJIMA, Y

KIMURA, J

UCHINO, J

ISSELHARD, W

FISCHER, JH

机构：

[1] The First Department of Surgery, School of Medicine, Hokkaido University, Sapporo, 060, N-15, W-7, Kita-ku

[2] The Institute of Experimental Medicine, Cologne University, Cologne

来源：

JAPANESE JOURNAL OF SURGERY | 1991年 / 21卷 / 01期

关键词：

ORTHOTOPIC LIVER TRANSPLANTATION; HEPATIC METABOLISM;

D O I：

10.1007/BF02470867

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The hepatocellular metabolic change after liver transplantation following 2 hr cold ischemia was investigated. Of 55 orthotopic liver transplanations in male Wistar rats, 47 animals were sacrificed at 3 hr, and 1, 2, 7 and 30 days to determine hepatic metabolite levels, in the form of adenine nucleotides, lactate and glycogen. Using the other 8 recipients, biochemical examinations were done at 1, 3, 5, 7, 30 and 60 days and metabolic levels estimated at 60 days. The SGOT and SGPT levels decreased gradually after a remarkable increase on the first postoperative day, while the alkaline phosphatase level revealed a peak value at 30 days. All levels recovered to within the normal range in 60 days. The total adenine nucleotide level reached the normal range within 3 hr following the blood reflow and remained at a normal level thereafter. However, all the metabolic levels apart from total adenine nucleotides deteriorated to reach their worst level at 7 days. The results of this investigation indicate that the posttransplanted deterioration of metabolic levels were possibly caused by the imperfect oxygenation due to cellular edema after blood reflow. However, the levels of these metabolites recovered within 60 days after transplanation.

引用

页码：57 / 62

页数：6

共 18 条

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