HYPERCALCEMIA AND ECTOPIC SECRETION OF PARATHYROID-HORMONE BY AN OVARIAN-CARCINOMA WITH REARRANGEMENT OF THE GENE FOR PARATHYROID-HORMONE

被引：114
作者：
NUSSBAUM, SR
GAZ, RD
ARNOLD, A
机构：
[1] MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114
[2] MASSACHUSETTS GEN HOSP,SURG SERV,BOSTON,MA 02114
[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1990年 / 323卷 / 19期
关键词：
D O I：
10.1056/NEJM199011083231907
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
HYPERCALCEMIA accompanied by elevated serum concentrations of parathyroid hormone (PTH) is the cardinal feature of primary hyperparathyroidism. The excessive production of PTH is due most often to a parathyroid adenoma, less often to parathyroid hyperplasia, and rarely to parathyroid carcinoma. In contrast, humoral hypercalcemia of cancer is now recognized to be a syndrome that is not dependent on PTH. Levels of the novel peptide PTH-related peptide are increased in the serum of most patients with squamous carcinoma,1 and through its binding to a common receptor for PTH and PTH-related peptide, it produces the biochemical features of hyperparathyroidism.2 Immunoradiometric assays for. © 1990, Massachusetts Medical Society. All rights reserved.
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页码：1324 / 1328
页数：5
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