FIBROSING CHOLESTATIC HEPATITIS IN A RENAL-TRANSPLANT RECIPIENT ASSOCIATED WITH THE HEPATITIS-B VIRUS PRECORE MUTANT

被引：30
作者：
BOOTH, JCL
GOLDIN, RD
BROWN, JL
KARAYIANNIS, P
THOMAS, HC
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,LONDON,ENGLAND
[2] ST MARYS HOSP,SCH MED,ACAD DEPT MED,LIVER UNIT,LONDON,ENGLAND
来源：
JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 04期
关键词：
IMMUNOSUPPRESSION; POLYMERASE CHAIN REACTION; PRECORE MUTANT;
D O I：
10.1016/0168-8278(95)80116-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A patient with evidence of chronic infection with hepatitis B virus (seropositive for hepatitis B surface antigen, and with antibody to hepatitis B e antigen) underwent renal transplantation, which subsequently failed. The patient developed abnormal liver function tests and 8 months after the removal of the transplanted kidney, hepatitis B virus DNA was detected in the serum in the absence of hepatitis B e antigen, Liver biopsy revealed the presence of fibrosing cholestatic hepatitis. Sequence analysis of the serum hepatitis B virus DNA showed, the presence of the pre-core mutant. This case shows that fibrosing cholestatic hepatitis can occur outside the setting of liver transplantation, and coincided with the development of the pre-core mutant of hepatitis B virus.
引用
收藏
页码：500 / 503
页数：4
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