EVIDENCE THAT SEROTONIN STIMULATES A PROLACTIN-RELEASING FACTOR IN THE RAT

被引：74
|
作者：
GARTHWAITE, TL
HAGEN, TC
机构：
[1] VET ADM CTR, DEPT MED, ENDOCRINE METAB SECT, WOOD, WI 53193 USA
[2] MED COLL WISCONSIN, MILWAUKEE, WI 53233 USA
来源：
NEUROENDOCRINOLOGY | 1979年 / 29卷 / 03期
关键词：
D O I：
10.1159/000122925
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulation of plasma PRL levels, respectively. Fluoxetine, a serotonin reuptake inhibitor, plus 5-hydroxytryptophan, the immediate precursor of serotonin, markedly stimulated both plasma PRL and plasma PRF-like activity. Neither fluoxetine, 5-hydroxytryptophan, nor the combination directly stimulated PRL release from rat pituitary tissue in vitro. Serotonergic stimulation may augment PRL release via a PRF.
引用
收藏
页码：215 / 220
页数：6
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