SYNTHESIS OF CYCLIC-PEPTIDES ON SOLID SUPPORT

We describe a general method for the solid-phase synthesis of cyclic peptides containing an Asp residue in their sequence. Boc-Asp-OFm is linked to PAM resin through the beta-carboxylic function; the linear precursor is then assembled by classical Boc/Benzyl strategy. Cyclization is accomplished by the BOP method; HF deprotection and cleavage afford the cyclic peptide as a single product.