INHIBITION OF CELL-CYCLE PROGRESSION BY THE ALTERNATIVELY SPLICED INTEGRIN BETA(1C)

被引：116

作者：

MEREDITH, J ^{[1
]}

TAKADA, Y ^{[1
]}

FORNARO, M ^{[1
]}

LANGUINO, LR ^{[1
]}

SCHWARTZ, MA ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT PATHOL, NEW HAVEN, CT 06520 USA

来源：

SCIENCE | 1995年 / 269卷 / 5230期

关键词：

D O I：

10.1126/science.7545312

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Integrins regulate cell growth, differentiation, and behavior in many systems. Integrin beta(1C) (beta(1S)) is an alternatively spliced variant of integrin beta(1) with a specific cytoplasmic domain and is expressed in several human tissues. Human beta(1C) transiently expressed in mouse 10T1/2 fibroblasts showed a diffuse pattern of cell surface staining, whereas beta(1) localized to focal adhesions. Moderate concentrations of beta(1C) had no effect on actin stress fibers or focal adhesions, but markedly inhibited DNA synthesis. Inhibition by beta(1C) mapped to the late G(1) phase of the cell cycle, near the G(1)-S boundary. Thus, alternative splicing of beta(1) results in transmission of distinct signals that may regulate growth in vivo.

引用

页码：1570 / 1572

页数：3

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