Bosentan monohydrate

In the title compound, C27H29N5O6S center dot H2O {systematic name: 4tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2(pyrimidin-2-yl) pyrimidin-4-yl] benzene-1-sulfonamide monohydrate], the dihedral angle between the mean planes of the pyrimidine rings is 27.0 (1)degrees. The dihedral angle between the mean planes of the benzene rings is 47.7 (8)degrees, forming a Ushaped channel around the chain of twisted pyrimidine rings. The crystal packing is stabilized by O-H center dot center dot center dot O, O-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds with a single water molecule, and weak O-H center dot center dot center dot N intermolecular interactions between the hydroxy group and one of the pyrimidine rings producing an two-dimensional supramolecular array in the bc plane. The title compound studied was a merohedral twin with the major component being approximately 57%.