FORMATION OF FORMALDEHYDE IN POLYETHYLENEGLYCOL AND IN POLOXAMER UNDER STRESS CONDITIONS

被引：13

作者：

FRONTINI, R ^{[1
]}

MIELCK, JB ^{[1
]}

机构：

[1] UNIV HAMBURG,INST PHARM,DEPT PHARMACEUT TECHNOL,D-20146 HAMBURG,GERMANY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 114卷 / 01期

关键词：

DEGRADATION; POLYETHYLENE GLYCOL; POLOXAMER; FORMALDEHYDE; BENDROFLUMETHIAZIDE; HYDROFLUMETHIAZIDE;

D O I：

10.1016/0378-5173(94)00221-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bendroflumethiazide (BFMT) hydrolyses to 5-trifluormethyl 2,4-disulfoamoylaniline (TFSA) and phenylacetaldehyde. In solid dispersions of BFMT in polyethylene glycol 6000 (PEG) and poloxamer 188 (PPEO) an unknown product was detected, isolated and identified as hydroflumethiazide (HFMT). HFMT was produced by the reaction of TFSA with formaldehyde being formed from PEG and from PPEO under stress conditions.

引用

页码：121 / 123

页数：3

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