TUMORIGENICITY IN HUMAN-MELANOMA CELL-LINES CONTROLLED BY INTRODUCTION OF HUMAN CHROMOSOME-6

被引:343
作者
TRENT, JM [1 ]
STANBRIDGE, EJ [1 ]
MCBRIDE, HL [1 ]
MEESE, EU [1 ]
CASEY, G [1 ]
ARAUJO, DE [1 ]
WITKOWSKI, CM [1 ]
NAGLE, RB [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92712
关键词
D O I
10.1126/science.2300817
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chromosome banding analysis of human malignant melanoma has documented the nonrandom alteration of chromosome 6. To determine the relevance of chromosome 6 abnormalities in melanoma, a normal chromosome 6 was directly introduced into melanoma cell lines. The resulting (+6) microcell hybrids were significantly altered in their phenotypic properties in culture and lost their ability to form tumors in nude mice. The loss of the chromosome 6 from melanoma microcell hybrids resulted in the reversion to tumorigenicity of these cells in mice. The introduction of the selectable marker (psv2neo) alone into melanoma cell lines had no effect on tumorigenicity. These results support the idea that one or more genes on chromosome 6 may control the malignant expression of human melanoma.
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页码:568 / 571
页数:4
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