INTERACTION OF MEMBRANE MODIFYING PEPTIDE ANTIBIOTICS FROM TRICHODERMA-VIRIDE WITH LEUKOCYTES

被引：34
作者：
BESSLER, WG [1 ]
OTTENBREIT, B [1 ]
IRMSCHER, G [1 ]
JUNG, G [1 ]
机构：
[1] UNIV TUBINGEN,INST ORGAN CHEM,D-7400 TUBINGEN 1,FED REP GER
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 01期
关键词：
D O I：
10.1016/0006-291X(79)91652-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bovine, rat, and mouse leukocytes were exposed to the pore-forming antibiotics alamethicin, suzukacillin, and trichotoxin isolated from the fungus Trichodermaviride. The compounds caused cell lysis around 5×10-5 mol/l; in rat mast cells histamine release was found simultaneously. For bovine and mouse lymphocytes, the compounds inhibited thymidine incorporation into DNA at sublytic concentrations around 2×10-6 mol/l. Lymphocyte stimulation by mitogens was inhibited at concentrations below 10-6 mol/l. We suggest that pore formation or alterations of membrane conductivity influence the proliferation of B- as well as of T-lymphocytes. © 1979.
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页码：99 / 105
页数：7
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